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No Ovarian Protection in Cancer With GnRH Agonist(2)

After more than 5 years of follow-up, women who received a gonadotropin-releasing hormone agonist (GnRHa) did not have higher rates of ovarian reserve or pregnancy, as compared with women who received chemotherapy without the GnRHa. Premature ovarian failure had significant associations with patient age, the conditioning regimen for hemopoietic stem cell transplant, and cumulative dose of cyclophosphamide but not the use of a GnRHa, as reported online in the Journal of Clinical Oncology.

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Long-term Outcomes of Preventing Premature Menopause During Chemotherapy

Compared with receiving chemotherapy alone, women with breast cancer who also received the hormonal drug triptorelin to achieve ovarian suppression had a higher long-term probability of ovarian function recovery, without a statistically significant difference in pregnancy rate or disease-free survival, according to a study in the December 22/29 issue of JAMA.

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Hormonal Therapy May Prevent Ovarian Failure and Preserve Fertility in Breast Cancer

Young women undergoing chemotherapy for breast cancer may be more likely to remain fertile if they also receive hormonal treatment, according to new research presented to the 2015 European Cancer Congress on Monday and published simultaneously in Annals of Oncology.

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Biological Clock Ticking? Egg Freezing Now an Option

Reproductive specialists have frozen the eggs of women facing chemotherapy or radiation for decades. But in 2012, the American Society for Reproductive Medicine essentially endorsed the practice as an elective procedure by declaring that egg freezing was no longer considered experimental. Since then, the egg-freezing business has ramped up at fertility centers across the country.

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Unused Embryos Pose Difficult Issue: What to Do With Them

In storage facilities across the nation, hundreds of thousands of frozen embryos — perhaps a million — are preserved in silver tanks of liquid nitrogen. Some are in storage for cancer patients trying to preserve their chance to have a family after chemotherapy destroys their fertility. But most are leftovers from the booming assisted reproduction industry. And increasingly families, clinics and the courts are facing difficult choices on what to do with them — decisions that involve profound questions about the beginning of life, the definition of family and the technological advances that have opened new reproductive possibilities.