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New Drug Compounds Show Promise Against Endometriosis

Two new drug compounds – one of which has already proven useful in a mouse model of multiple sclerosis – appear to be effective in treating endometriosis, a disorder that, like MS, is driven by estrogen and inflammation, scientists report in Science Translational Medicine.

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New Research Provides Better Understanding of Endometriosis

A mouse model of endometriosis has been developed that produces endometriosis lesions similar to those found in humans, according to a report published in The American Journal of Pathology. This model closely mirrors the human condition as an estrogen-dependent inflammatory disorder, and findings from the study suggest that macrophages present in shed endometrium contribute to the development of the lesions.

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What’s the Latest on Hormone Replacement for Prevention?

Hormone replacement therapy (HRT) is the use of estrogen alone (for women who have had a hysterectomy) or combined with progestin (for women with an intact uterus). It is primarily used in menopausal women for relief of symptoms, particularly hot flashes. For many years, providers recommended that women continue to take HRT after menopause to prevent chronic conditions such as heart disease.

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Post-Menopausal Study’s Final Results

After more than a decade and over 100 journal articles, the final results are in from the Women’s Health Initiative, the study that startled millions of post-menopausal women and doctors in 2002 by linking the commonly prescribed estrogen plus progestin hormone replacement therapy to increased risk of breast cancer and heart disease.