After more than 5 years of follow-up, women who received a gonadotropin-releasing hormone agonist (GnRHa) did not have higher rates of ovarian reserve or pregnancy, as compared with women who received chemotherapy without the GnRHa. Premature ovarian failure had significant associations with patient age, the conditioning regimen for hemopoietic stem cell transplant, and cumulative dose of cyclophosphamide but not the use of a GnRHa, as reported online in the Journal of Clinical Oncology.
Tag: ovarian reserve
Exposure to Endocrine-Disrupting Chemicals Associated with Earlier Age at Menopause
In a study to be presented at the 68th Annual Meeting of the American Society for Reproductive Medicine, researchers from Washington University in St. Louis show for the first time the potential effects of endocrine-disrupting chemicals on ovarian reserve.
About the Fertility Clock
The Fertility Clock was developed by Dr. John Jain and Brigitte Mueller as an educational element for the film “My Future Baby: Breakthroughs In Modern Fertility”.
The Fertility Clock provides a simple graphic that can be used to estimate the monthly chance of having a baby.
Age-related decline in natural fertility is due to both decreases in egg count and egg quality; egg quality refers to an egg’s ability to create a chromosomally normal embryo.
As seen in the Fertility Clock, monthly birth rates remain relatively stable through age 35 despite a 90% drop in overall egg counts. Thereafter, birth rates decline more rapidly probably as a result of waning egg quality.
The data used to create the Fertility Clock was taken from landmark works in the fields of Population Research and Developmental Biology.
Using data from historical populations (1) and the most comprehensive study of ovarian reserve to date (2), estimates for monthly birth rates and egg counts were plotted in an age-dependent manner, from birth to menopause.
The rates depicted on the Fertility Clock estimate the experience for most women. As with all biological systems exceptions do exist.
(1) Wallace WH, Kelsey TW. Human ovarian reserve from Conception to the Menopause. PLoS One. 2010 Jan 27;5(1):e8772.
(2) Bongaarts, J. and Potter, R.G. (1983). Fertility, Biology, and Behavior: An analysis of the proximate determinants. New York, NY: Academic Press, Inc.