Fertility Clock Headlines, Fertility Headlines

A Key Role for CEP63 in Brain Development and Fertility Discovered

Today in Nature Communications, scientists at the Institute for Research in Biomedicine (IRB Barcelona) provide molecular details about Seckel Syndrome, a rare disease that causes microcephaly, or small brain, and growth delays. A joint study conducted by Travis Stracker and Jens Lüders indicates that the protein CEP63 plays a key role during brain development as it is involved in the correct division of stem cells in this organ. Furthermore, the researchers have discovered that CEP63 is associated with sperm production—an unknown function until now.

Fertility Clock Headlines, Fertility Headlines

Effect of Fertility on Perinatal Outcomes

The impact of ART in a fertile setting cannot be studied because otherwise fertile women cannot be randomly assigned to IVF treatment due to ethical concerns. Recent advances in technology, however, could present an opportunity. Couples with proven fertility may elect to undergo preimplantation genetic testing, and the perinatal outcome of these pregnancies could be used to evaluate an unstudied group: fertile women utilizing ART. An adverse impact observed among them could represent the adverse impact of ART itself.

Fertility Clock Headlines, Fertility Headlines

Team Identifies Gene Responsible for Some Cases of Male Infertility

In the most severe form of male infertility, men do not make any measurable levels of sperm. This condition, called azoospermia, affects approximately 1 percent of the male population and is responsible for about a sixth of cases of male infertility.
Oftentimes men with azoospermia don’t know the underlying cause of their condition. But new research led by University of Pennsylvania scientists suggests that mutations in an X chromosome gene called TEX11 are responsible for a significant number of cases of infertility—an estimated 1 percent of cases of non-obstructive azoospermia.