Ovarian stimulation with letrozole, an aromatase inhibitor, results in significantly fewer multiple gestations compared with gonadotropin among couples with unexplained infertility, according to a large-scale randomized trial. However, the rate of multiple gestations was not significantly different between letrozole and clomiphene, researchers report in an article published in the September 24 issue of the New England Journal of Medicine.
Multiple-Birth Rates Lower With Letrozole Than Gonadotropin
