HOUSTON – Applying transdermal gels containing off-label testosterone and an experimental nonandrogenic progestin showed promise as a form of reversible contraception for men in a randomized, double-blind, controlled pilot study in 99 men.
Healthy male volunteers were randomized in three groups to apply gels containing 10 g of testosterone plus placebo or testosterone plus either 8 mg or 12 mg of Nestorone, an investigational synthetic nonandrogenic progestin. They were asked to apply the gels daily for 20-24 weeks, and 56 complied.
